CV: Fred Finkelman MD

Fred Finkelman, MD
Director, Division of Immunology
College of Medicine
University of Cincinnati

Practice Address:

Veterans Administration Medical Center
3200 Vine Street
Cincinnati, OH 45220

Education:

B.A. Queens College, New York City, NY
M.D. Yale University School of Medicine, New Haven, CT

Post Graduate Training:

Internship in Internal Medicine, Yale-New Haven Hospital, New Haven, CT
Residency in Internal Medicine, Yale-New Haven Hospital, New Haven, CT
Research Associate, Laboratory of Immunology, NIAID, NIH, Bethesda, MD
Fellow in Rheumatology, University of Texas-Southwestern Medical School, Dallas, TX

Licensure or Certification:

Maryland State Board of Medical Examiners
Ohio State Board of Medical Examiners
National Board of Medical Examiners
American Board of Internal Medicine
American Board of Internal Medicine, Rheumatology

Associations:

American Society for Clinical Investigation
American Association of Immunologists
American College of Rheumatology
American Rheumatology Association

Affiliations:

University Hospital, Cincinnati, OH
Veterans Administration Medical Center, Cincinnati, OH

Partial List of Publications:

Gause, W.C., R. Greenwald, M. Halvorson, P.Lu, W. diZhou, S.J. Chen, S.C. Morris, K. Lee, C. June, F.D. Finkelman, J.F. Urban and R. Abe. 1997. CD28-dependence of T cell differentiation to IL-4 production varies with the particular type 2 immune response. J. Immunol. 158:4082.
Madden, K.B., F.D. Finkelman, J.F. Urban, Jr., A. Svetic, W.C. Gause and I.M. Katona. The role of cytokines in helminth-induced mucosal mast cell hyperplasia. Submitted for publication.
Greenwald, R., P. Lu, M. Halvorson, X. Zhou, S. Chen, K.B. Madden, P.J. Perrin, S.C. Morris, R. Peach, F.D. Finkelman, J.F. Urban, Jr. and W.C.Gause. 1997. The role of CD80 and CD86 in the development of an in vivo type 2 immune response. J. Immunol. 158:4088.
Brunet, L.R., F.D. Finkelman, A.W. Cheever, M.A. Kopf and E.J. Pearce. 1997. IL-4 protects against TNF-a medicated cachexia and death during acute schistosomiasis. J. Immunol. 159:777-85.
Roes, J., M. Epstein, I. Wolowezuk, F. Finkelman, P. Matzinger and K. Rajewsky. Impaired T cell help in B cell-deficient mice. Submitted for publication.
Valenzona, H.O., S. Dhanoa, F.D. Finkelman, A. Namen and D.G. Osmond. Exogenous interleukin-7 as a proliferative stimulant of early precursor B cells in mouse bone marrow: efficacy of IL-7 injection, IL-7 infusion and IL-7 - anti-IL-7 antibody complexes. Submitted for publication.
Comoy, E.E., J. Pestel, C. Duez, G.A. Stewart, C. Vendeville, C. Fournier, F. Finkelman, A. Capron and G. Thyphronitis. 1998. The house dust mite allergen, Der pl, promotes type 2 responses by modulating the balance between IL-4 and IFN-g. J. Immunol., In press.
Greenwald, R.J., D. Nguyen, F.D. Finkelman, P.S. Linsley, A. Sharpe, J.F. Urban, Jr. and W.C. Gause. Neither CD 28 nor B7-2 is required for germinal center formation during a B7-dependent type 2 in vivo mucosal immune response. Submitted for publication.
Morris, S.C., R.L. Cofman and F.D. Finkelman. 1998. In vivo IL-4 responses to anti-IgD antibody are MHC class II-dependent, b2-microglobulin-independent, and Stat6-independent. J. Immunol. In press.
Grieder, F.B., B.K. Davis, X.D. Zhou, S.J. Chen, F.D. Finkelman and W.C. Gause. 1997. Kinetics of cytokine expression and regulation of host protection following infection with molecularly cloned Venezuelan equine encephalitis virus. Virology 233:302-12.

Research:

Regulation of lymphocyte activation and tolerization
Regulation of lymphopoiesis
Cytokine regulation of protective immunity
Cytokine regulation of allergic inflammation
Regulation of T lymphocyte cytokine production

Hospital Appointments:

Grants:

NIH. Cytokine enhancement of an anti-nematode vaccine. 1994-1998. Direct funding: $396,942.
NIH. Role of interleukin-4 in host immunity to nematodes. 1994-1998. Direct funding: $298,330.
National Arthritis Foundation (Biomedical Science Grant). Effects of membrane Ig crosslinking on the lifespan of mature B cells in vivo. 1995-1998. Direct funding: $208,332.
Veterans Administration Merit Award. Regulation of asthma by IL-4 and IL-5. 1997-2002. Direct funding approximately $460,000.
Genetics Institute. Regulation of asthma by IL-12. 1996-1998. Direct funding: $64,000.

Partial List of Presentations:

Symposium Speaker and Minisymposium Chair, AAI Annual Meeting, San Francisco, CA
Chicago Immunology Society, Chicago, IL
Cornell University College of Medicine, New York, NY
British Society for Parasitology Manchester, UK
University of Southern Ontario College of Medicine, London, Ontario, Canada
Case Western Reserve College of Medicine, Cleveland, OH
Genetics Institute, Cambridge, MA
Idiotype Meeting, Toulouse, France
Immunex Corporation, Seattle, WA
Australasian Immunology Society Annual Meeting, Perth, Australia
AAAAI Annual Meeting, Washington, DC
Johns Hopkins College of Medicine, Baltimore, MD
Aspen Allergy Meeting, Aspen, CO
Monod Conference on Parasitology, Aussois, France
British Society of Immunology Meeting, Harrogate, UK