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Alzheimer's Disease

Raloxifene Prevention of Alzheimer's Disease

04/22/1999

Question:

Does raloxifene have any effect in preventing dementia or Alzheimer`s such as estrogen might have?

Answer:

There have been no studies done to determine whether raloxifene has any effect in preventing Alzheimer`s disease. Raloxifine is a `tissue specific` selective estrogen receptor modulator (SERM). Once raloxifine binds to estrogen receptors, estrogen specific genes that are present in a variety of tissues (especially bones) are stimulated. This results in an increase in bone mineral density.

Additional laboratory research and large scale studies are needed to learn exactly how estrogen may protect women from Alzheimer`s disease.

The Alzheimer`s Disease Cooperative Study (ADCS) has just completed a multi-center study on estrogen replacement therapy in postmenopausal women with Alzheimer`s disease. Results from this study are forthcoming. Stay tuned . . .

Related Resources:

Alzheimers Disease Education and Referral Center

For more information:

Go to the Alzheimer's Disease health topic, where you can:

Response by:

Jon Stuckey, PhD
Formerly
Case Western Reserve University

Alan J Lerner, MD
Professor of Neurology
School of Medicine
Case Western Reserve University