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Wednesday, June 3, 2015
Protein and Medicine
How can one handle eating protein when it interfers with the medication? I try to avoid eating protein and would like suggestion on including protein in my diet without interfering with my medicine.
Protein in the diet interferes with the absorption of Sinemet (carbidopa/levodopa). The breakdown products of proteins are amino acids. These are absorbed into the bloodstream from the gut by a transporter system. This same system also is responsible for absorption of Sinemet from the gut. Thus when protein and Sinemet are in the gut at the same time, less Sinemet is absorbed. Taking Sinemet 1/2 hour before or 1 hour after meals helps minimize this problem. Adding dopamine agonists (Mirapex, Requip, Permax, Parlodel) which are not absorbed by this transporter system also helps.
Arif Dalvi, MD
College of Medicine
University of Cincinnati