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Parkinson's Disease

ORAL GLUTATHIONE

05/24/2000

Question:

Is oral glutathione an optional treatment for PD?

Answer:

Glutathione in both the oral and IV forms is being investigated in the management of PD. The idea behind it is that it may have antioxidant properties. When dopamine is being broken down in the brain as part of its metabolism oxygen radicals are formed. These are believed to be toxic to the brain cells and may accelerate the death of dopamine producing cells. Using antioxidants helps to scavenge or clean up these harmful oxygen radicals and may thereby help slow progression of PD. That is the theory. Whether glutathione in practise does help slow progression of PD remains to be tested. It is certainly not a part of standard management of PD.

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Response by:

Arif Dalvi, MD
Assistant Professor
College of Medicine
University of Cincinnati