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NetWellness is a global, community service providing quality, unbiased health information from our partner university faculty. NetWellness is commercial-free and does not accept advertising.
Friday, May 24, 2013
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NetWellness is a global, community service providing quality, unbiased health information from our partner university faculty. NetWellness is commercial-free and does not accept advertising.
Friday, May 24, 2013
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Parkinson's Disease |
Medication doesn't last as long05/27/1998 |
I have Parkinson's disease for the last 4 years for which I take Sinemet. I am finding that my medication doesn't last as long. Should I increase the dose or take it more frequently?
What you describe is a common phenomenon called "wearing off". The dose of Sinemet which would last 5-8 hours begins to last 2-4 hours or even less. It is part of disease progression and may be related to the pulsatile form in which Sinemet is delivered to the brain--with peaks and troughs rather than at a steady state.Reducing the dosing interval is an obvious solution. However, other approaches include addition of Tasmar (tolcapone) or dopamine agonists such as Mirapex (pramipexole), Requip (ropinerole) or Permax (pergoloide).
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Arif Dalvi, MD Assistant Professor College of Medicine University of Cincinnati |
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