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Parkinson's Disease

Medication doesn't last as long



I have Parkinson's disease for the last 4 years for which I take Sinemet. I am finding that my medication doesn't last as long. Should I increase the dose or take it more frequently?


What you describe is a common phenomenon called "wearing off". The dose of Sinemet which would last 5-8 hours begins to last 2-4 hours or even less. It is part of disease progression and may be related to the pulsatile form in which Sinemet is delivered to the brain--with peaks and troughs rather than at a steady state.

Reducing the dosing interval is an obvious solution. However, other approaches include addition of Tasmar (tolcapone) or dopamine agonists such as Mirapex (pramipexole), Requip (ropinerole) or Permax (pergoloide).

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Response by:

Arif Dalvi, MD
Assistant Professor
College of Medicine
University of Cincinnati