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FANA titer



A few years ago I had an FANA titer of 1:320, speckled pattern. Now, it is 1:1280, speckled. What are the implications/what does this mean? (NOTE: I have been diagnosed with Sjogren`s syndrome and my former rheumatology doctor was also monitoring me for lupus.)


An increase in FANA titer does not necessarily mean an increase in disease activity. However, if it continues to be high, you may ask your rheumatologist for a detailed physical exam and evaluation for any flares - sometimes they require further testing for antibodies such as anti-SSA, anti-RNP and anti-DNA, complement levels, urine tests etc.

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Response by:

Ram Raj   Singh, MD Ram Raj Singh, MD
Associate Professor of Clinical Medicine
College of Medicine
University of Cincinnati