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Parkinson's Disease




Clozaril has been prescribed for hypersexual problems ,presumably caused by 1800mg. of sinemet daily. How long on Clozaril before benefits become apparent? Daily dose is 25mg.


Hypersexuality on high doses of Sinemet or dopamine agonists is due to excess dopaminergic activity in the mesolimbic system as a result of these medications. Clozaril and Seroquel are two medications that can block this activity, while sparing the activity in the basal ganglia that is required for good motor function. Since both drugs work by changing chemical balances in the brain it may be two to three weeks before results are noticed. Higher doses may be required if the low dose does not work in this time period.

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Response by:

Arif Dalvi, MD
Assistant Professor
College of Medicine
University of Cincinnati