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Parkinson's Disease

CLOZARIL AND BLOOD COUNT>

04/17/2001

Question:

CLOZARIL can lower white cell count. Is this more likely on high doses or is there the same probability whether taking 12.5 mg or 200 mg daily? In other words is it a case of the higher the dose the higher the risk?

Answer:

About 1% of patients on Clozaril (clozapine)develop neutropenia (drop in white cell count). This is an `idiosyncratic` reaction. Which is to say it is unpredictable and does not depend on the dose. Seroquel (quetiapine) is a newer drug which is similar to clozapine and does not have the risk of neutropenia and thus does not require weekly blood tests.

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Response by:

Arif Dalvi, MD
Assistant Professor
College of Medicine
University of Cincinnati