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Parkinson's Disease

ADDING COMTAN(entacapone)

05/06/2002

Question:

Neurologist has prescribed Comtan to be added to medications. Present meds are Sinemet 1800mg. daily: Mirapex 1.825 daily and Clozaril 25mg. daily Comtan is to be taken 3 times daily 25mg. each time. Question is: Should the Mirapex not be reduced as the new med. Comtan is introduced. Thanking you in anticipation of a speedy rreply.

Answer:

Comtan will increase the delivery of Sinemet to you brain. As a result side effects such as hallucinations or dyskinesias are possible. If they do occur your doctor may reduce the dose of Mirapex and/or Sinemet. The exact adjustment should be discussed with your doctor.

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Response by:

Arif Dalvi, MD
Assistant Professor
College of Medicine
University of Cincinnati