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Osteoporosis

Evista and Fosamax Combination

06/07/2002

Question:

Have any studies been done which suggest that the combination of Evista and Fosamax works better for strong bones than either of the two used alone?

Answer:

One study suggested that the two drugs combined improve bone density slightly more than either drug alone, but it is very important to realize that bone density is not the most important factor. The most important factor is whether the two drugs together prevent more fractures. No study has demonstrated that the two drugs together prevent more fractures than either drug alone. What bone experts have concluded in the last couple of years is that the improvement in bone density on treatment drugs does not necessarily correlate with the reduction in fractures. Simply maintaining bone density may prevent as many fractures as improving bone density. Combination therapy is not routinely recommended.

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Response by:

Margery Gass, MD Margery Gass, MD
Formely, Professor, Clinical Obstetrics & Gynecology
College of Medicine
University of Cincinnati