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Prostate Cancer

Low PSA With Firm and Soft Side to Prostate

07/24/2002

Question:

If one`s PSA is very low but the DRE notices a soft side and a harder side of the prostate, but no nodules or irregularities outside of the differences in softness/firmness on each side, is a biopsy required? Secondly, with the PSA being low and only a hardness/softness issue without lumps/irregularites, is that a little more optimistic scenario that any biopsy might be negative (i.e., is hardness alone a *significant* sign)? Thank you very much!

Answer:

Hardness is a significant finding that does require biopsy even if the PSA is normal. The fact that the PSA is normal is optimisitc in that the liklihood of cancer would be higher with an elevated PSA. I hope this information is helpful to you.

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Response by:

Martin I Resnick, MD Martin I Resnick, MD
Formerly, Professor of Urology
School of Medicine
Case Western Reserve University