Home HealthTopics Health Centers Reference Library Research
Join us on Facebook Join us on Facebook Share on Facebook

Prostate Cancer

Low PSA With Firm and Soft Side to Prostate



If one`s PSA is very low but the DRE notices a soft side and a harder side of the prostate, but no nodules or irregularities outside of the differences in softness/firmness on each side, is a biopsy required? Secondly, with the PSA being low and only a hardness/softness issue without lumps/irregularites, is that a little more optimistic scenario that any biopsy might be negative (i.e., is hardness alone a *significant* sign)? Thank you very much!


Hardness is a significant finding that does require biopsy even if the PSA is normal. The fact that the PSA is normal is optimisitc in that the liklihood of cancer would be higher with an elevated PSA. I hope this information is helpful to you.

For more information:

Go to the Prostate Cancer health topic, where you can:

Response by:

Martin I Resnick, MD Martin I Resnick, MD
Formerly, Professor of Urology
School of Medicine
Case Western Reserve University