Pulmonary Fibrosis |
Interstitial prominence on chest film05/11/2007 |
I have a myopathy with proximal and resp. muscle weakness verified by emg/muscle bx and pft`s. I have a restrictive impairment on pft`s also with a decreased dlco (67%). On my chest film , it showed interstitial prominence and scattered granulomas. I had a HRCT that showed small amt of bibasilar interstitial changes . What does the interstitial prominence and granulomas mean? I have air hunger and dyspnea- worse with exertion. On a 6MW test, I did not desturate but did become tacycardic.On a stress echo, I did desaturate briefly but was very dyspneic which took a while to return to baseline. It showed poor exercise tolerance. I follow with my pulmonolgist q 6 mos with spirometry and dlco. Thanks for your help. Is there any other testing you recommend?
Many forms of myopathy can cause interstitial lung disease. A common type of myopathy that does this is called polymyositis. Interstitial lung disease associated with polymyositis can result in shortness of breath and a low blood oxygen level.
Fortunately, these types of interstitial lung disease can often be treated with medications such as:
- prednisone
- azathioprine
- cyclophosphamide
- or cyclosporin-A.
Sometimes additional tests such as bronchoscopy or lung biopsy are required in order to exclude other conditions that can cause interstitial changes on the x-ray (such as infection).
Another cause of shortness of breath (dyspnea) and a low diffusing capacity in polymyositis is pulmonary hypertension. Often, signs of pulmonary hypertension can be found on a cardiac echo. Pulmonary hypertension is treated with different drugs than interstitial lung disease.
Granulomas are benign scars on the lung, often due to previous infections by yeasts such as histoplasmosis.
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James N Allen, Jr, MD Clinical Professor of Pulmonary, Allergy, Critical Care & Sleep Medicine College of Medicine The Ohio State University |