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Bleeding and Clotting Disorders

Minus 5q-syndrome



My mother is 83 she has the Minus 5Q-Syndrome. She did not tolerate Revlimid well. The dr. would now like to start her on hydrea? What are the side effects? Will this cause leukemia?


Typically hydroxyurea (Hydrea) is well-tolerated with minimal side effects. The risk of developing leukemia is also quite low with this drug. It is not a commonly used drug in MDS (which is what I presume she has given your description of the 5q-syndrome), so it is not clear as to the reason it is being used.

I would suggest asking her doctor the reason and rationale for the drug as it is difficult to say much more without more information and having a chance to evaluate and examine her in person.

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Response by:

Spero R Cataland, MD Spero R Cataland, MD
Associate Professor of Clinical Internal Medicine
College of Medicine
The Ohio State University