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Prostate Cancer

Increasing PSA Levels With Negative Biopsies



Over a 7 year period, PSA increased from 5 to 11. Three biopsies done, all negative, BPH with minimal symtoms, prostrate is enlarged but normal DRE. Any help on what can cause this or should I keep getting biopsies?


An elevated PSA can result from several causes. One being prostate cancer, however, an enlarged prostate, inflammation or infection of the prostate are other potential causes of an elevated PSA (among others). In patients whom have had negative biopsies in the past, we often watch the PSA velocity and percent free PSA as indicators for future biopsies.

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Response by:

Lee E Ponsky, MD Lee E Ponsky, MD
Associate Professor of Urology
School of Medicine
Case Western Reserve University