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Myasthenia Gravis

Collagen and hyaluronic facial fillers



If botox injections for cosmetic purposes are not a good idea for people with MG, would collagen and/or the new Hyaluronic facial fillers (such as Restylane) be safe, please?

Thank you for your help.


Botox works at the neuromuscular junction, the same site of disease activity as myasthenia, so it naturally can worsen the disease. I have found no papers or studies to indicate that the hyaluronic acid fillers cause problems with myasthenia gravis. As to their overall safety or usefulness for facial augmentation, I have no experience and can make no comment.

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Response by:

Robert W Neel, IV, MD Robert W Neel, IV, MD
Assistant Professor of Neurology
College of Medicine
University of Cincinnati