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Thursday, December 12, 2013
Sickle Cell Anemia
Sickle Cell Anemia Chromosome Informatiion
Which chromosome does the mutation occur upon? Which gene? Where on the chromosome, on both or on one? Thank you
The mutation occurs in the 6th codon of the beta globin gene located on chromosome 11. If one gene is affected the individual has sickle trait (carrier) and if both genes are affected the individual has sickle cell disease.
Anthony D Villella, MD
Formerly, Assistant Professor of Pediatrics
School of Medicine
Case Western Reserve University