Home HealthTopics Health Centers Reference Library Research
Join us on Facebook Join us on Facebook Share on Facebook

Inherited Disorders and Birth Defects

Balanced Translocation and Learning

02/08/2008

Question:

Can a balanced translocation cause a child to have learning disabilities? If so, how would these disabilities manifest themselves? Are there studies in the literature that you could refer me to?

Answer:

As you know, a balanced translocation occurs when two pieces of chromosomes break off and switch places with each other. If all the chromosomal material is present, but rearranged – that is, switched places (translocated) - this person should have no health problems or learning problems since all the chromosomal material needed is present and functioning properly. This is called a balanced translocation.

While there should be no problems if the translocation is balanced, sometimes if the breaks in the chromosomes happen to be in the middle of a gene, it could disrupt normal functioning of that gene or genes. Or, sometimes, what looks to be “balanced” is not - that is, there is a loss or addition of chromosomal material that was not seen on routine chromosome testing - perhaps this could lead to problems. This could potentially lead to someone having learning disabilities.

Additionally, learning disabilities in a person who has a translocation may have nothing to do with the translocation. There are hundreds of reasons for learning disabilities - so it may not be connected to a chromosomal translocation at all.

You may want to talk to your doctor or to a genetic counselor if you have specific questions regarding the basis for learning disabilities. You can locate a genetics center through the National Society of Genetic Counselors’ Resource website.

Related Resources:

National Society of Genetic Counselors Resource Center

For more information:

Go to the Inherited Disorders and Birth Defects health topic, where you can:

Response by:

Anne   Matthews, RN, PhD Anne Matthews, RN, PhD
Associate Professor of Genetics
School of Medicine
Case Western Reserve University