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Pulmonary Fibrosis

Losartan

05/07/2008

Question:

Please comment if Losartan may help fight Pulmonary Fibrosis.Thanks

Answer:

Losartan is an Angiotensin II Receptor Blocker that is commonly used to treat heart failure and high blood pressure. There is experimental laboratory and animal studies that suggest that this class of drugs may be useful in some types of interstitial lung disease. However, not all of the experimental studies agree and there are no large randomized, placebo-controlled studies of Angiotensin II Receptor Blockers in humans with pulmonary fibrosis. In summary, there is some information that these drugs may be effective in laboratory animals, particularly if given very early but no indication of whether they help, hurt, or do nothing for humans with pulmonary fibrosis. At present, they are not recommended as treatment for pulmonary fibrosis.

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Response by:

James N Allen, Jr, MD James N Allen, Jr, MD
Clinical Professor of Pulmonary, Allergy, Critical Care & Sleep Medicine
College of Medicine
The Ohio State University