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Hemochromatosis

Hemochromatosis with up/down iron levels?

05/27/2008

Question:

I`ve had a high iron reading approx. 10 years ago (185 mcg/dL serum and 61% saturation). It was fine (middle of normal) for 9 years at yearly exams, but returned to high reading again (195 mcg/dL serum and 53% saturation). Could this be hemochromatosis, or would the temprorary return to normal exclude that diagnosis? The only other out-of-range values were bilirubin (total and direct were measured) that have been high normal but were above normal limits during the two occassions the iron was high.

Answer:

Elevated saturation in disease may vary over time; however, at least two of these were abnormal. In addition, bllirubin levels being abnormal suggests possibility of liver dysfunction. You should consider undergoing genetic testing to rule out hemochromatosis as a possible cause.

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Response by:

Mark   Wurster, MD Mark Wurster, MD
Former Clinical Assistant Professor of Internal Medicine
College of Medicine
The Ohio State University