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Mixing Anti-depressants



I have been taking Zoloft 60mg 1xdaily for a yr. prescribed for mild depression. I was prescribed Cymbalta 30mg 1xdaily for Fibromyalgia pain. Is there a chance for Serontin syndrome? I take the Zoloft in the morning and Cymbalta at night. If the Cymbalta is increased, what are the dangers?


My first question would be if this regimen was prescribed by two different physicians. If so, some communication between the two must happen since this is somewhat unusual. 

Although serotonin syndrome would be uncommon, it is very likely that serotonin side effects might increase with the combination. If possible the simplest regimen might be using a larger dose of cymbalta instead of two medications.

For more information:

Go to the Depression health topic, where you can:

Response by:

Nicholas A Votolato, RPh BCPP Nicholas A Votolato, RPh BCPP
Assistant Professor of Pharmacy
College of Pharmacy
Assistant Professor of Psychiatry, Emeritus
College of Medicine
The Ohio State University