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Bleeding and Clotting Disorders

Excessive Protein S and Pulmonary Embolysms



I was just hospitalized with multiple pulmonary emboli. No clots were found in legs. Report said there was too much protein S which affected the clotting. I had multiple pulmonary blood clots back in 2005. I have found info on protein S deficiency but nothing on the effects of too much protein S. I am on coumadin. Can you explain how too much protein S affects clotting. Thank you


While it is difficult to make any specific comments on your case, protein S is one of the natural anticoagulants, and having "higher" levels is not associated with any problems. Many things can affect the measurement of protein S levels as well, so I would not be concerned about this laboratory test.

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Response by:

Spero R Cataland, MD Spero R Cataland, MD
Associate Professor of Clinical Internal Medicine
College of Medicine
The Ohio State University