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Mouth Diseases

Face Muscle Wasting

10/21/2009

Question:

What type of disease causes brownish spots inside the mouth and on toungue. and causes huge face muscle wasting

Answer:

In response to your question, there are  a number of disease entities that may be related to the physical signs you describe.

Generally the common "brown" pigmentation in the oral cavity would be related to melanin pigmentation.

One such disease that may be associated with both muscle wasting and pigmentation is known as "Addison's disease" or hypoadrenalcorticoism. This disease is associated with adrenal hormone deficiency and the cause of disease can be the result of autoimmune insult, infection (TB or HIV) or tumors of the adrenal gland. There is both a primary disease and secondary adrenal insufficiency disease, I will concentrate on the Primary form as it results in the mucosal and skin hyperpigmentation.


Symptoms for the disease include but are not limited to; chronic progressive fatigue, muscle weakness, loss of appetite, weight loss, positional hypotension, nausea, vomiting, diarrhea, hypoglycemia, and hyperpigmentation (Brown/Black/Blue, freckles or spots or large areas of discoloration).

The proposed cause of the discoloration is related to increase MSH or Melanin Stimulating Hormone being produced that in response to a breakdown of a negative feed back loop in the ACTH (Adrenal Corticotropic Hormone) cascade. The adrenal gland is damaged and the ACTH stimulation continues in response to the decrease in adrenal corticoid production. I hope this is what you are looking for, o
therwise you may want to have an Endocrinologist try and answer this question.

Thank you for visiting NetWellness.

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Response by:

Richard J Jurevic, DDS, PhD Richard J Jurevic, DDS, PhD
Formerly, Assistant Professor of Biological Sciences
School of Dental Medicine
Case Western Reserve University