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Pulmonary Fibrosis

What Drug? - Updated Response



What is the most effective medication to overcome the shortness of breath, and weakness?


There is no perfect drug for pulmonary fibrosis. Pirfenidone, a drug that may interrupt some of the scar tissue formation in a certain type of pulmonary fibrosis called idiopathic pulmonary fibrosis, is currently being evaluated by the FDA. The drug showed some benefit in clinical trials and may help some people with the disease. It is expected that the FDA will make a final decision about whether to approve it by May 4, 2010.

You should address this issue with your doctor and make sure that there are not other medical issues that could make you weak like low thyroid, electrolyte (blood salts), kidney function, liver function, heart function or drug effects (steroid withdrawal).

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Response by:

Clay B Marsh, MD Clay B Marsh, MD
Vice Dean of Medicine Administration
Professor of Molecular Virology, Immunology & Medical Genetics
Professor of Veterinary Biosciences
Associate Vice President of Health Sciences Research Administration
College of Medicine
The Ohio State University

James N Allen, Jr, MD James N Allen, Jr, MD
Clinical Professor of Pulmonary, Allergy, Critical Care & Sleep Medicine
College of Medicine
The Ohio State University