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Parkinson's Disease




Is clozaril or seroquil ever used for confusion (especially at night) when the PWP does not have hallucinations or paranoia? If so, is this something that can be stopped when the confusion lessens? What are the side effects? I realize clozaril needs weekly blood tests. Other than that, what are the differences between the two drugs.

If these drugs are not used for confusion, what can be done to improve the confusion?


Both Clozaril and Seoquel are atypical antipsychotic drugs. They are also very useful in PD, helping to control drug-induced hallucinations and psychosis. Neither drug helps the confusional state per se, and there are no drugs availble that help in this regard. Simply reducing the PD meds as far as possible may be helpful. Preliminary evidence indicates that Seroquel may be just as good as Clozaril, with the advantage of not needing weekly blood tests.

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Response by:

Arif Dalvi, MD
Assistant Professor
College of Medicine
University of Cincinnati